Ernst Boris Chain

Ernst Boris Chain - Biochemists, Facts and Family

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Ernst Boris Chain's Personal Details

Sir Ernst Boris Chain was a biochemist who won the Nobel Prize in Medicine in 1945

InformationDetail
BirthdayJune 19, 1906
Died onAugust 12, 1979
NationalityGerman
FamousScientists, Biochemists
SpousesAnne Chain (m. 1948–1979), his death)
Birth PlaceBerlin, Germany
GenderMale
Sun SignGemini
Born inBerlin, Germany
Famous asBiochemist
Died at Age73

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Ernst Boris Chain's photo

Who is Ernst Boris Chain?

Sir Ernst Boris Chain was a biochemist whose works earned him the prestigious Nobel Prize for Physiology or Medicine in 1945. He jointly won the award with the fellow scientists Sir Alexander Fleming and Sir Howard Walter Florey. The trio was instrumental in developing the world’s first antibiotic, penicillin, which proved to be of immense use in the treatment of wounded soldiers during the World War II. Ernst Boris Chain developed an interest for chemistry from a young age and subsequently completed his graduation in Chemistry and Physiology from the Friedrich Wilhelm University. He later engaged in research work at the Institute of Pathology, Charité Hospital in Berlin, until he was forced to shift to England due to anti-semitic policies of Hitler. He worked in different capacities at Cambridge, Oxford University, and at the University of London. Towards the later part of his career he served as the Director of the International Research Centre for Chemical Microbiology, Superior Institute of Health, in Rome. He along with pathologist Howard Florey isolated and worked on pencillin, which was found by Alexander Fleming almost a decade earlier. The duo was successfully able to identify its antibiotic properties. Post his retirement, he continued delivering lectures.

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Childhood & Early Life

Ernst Boris Chain was born on 19 June 1906, at Berlin, to chemist and industrialist, Dr. Michael Chain, and his wife, Margarete Eisner.

He completed his school education at Luisengymnasium at Berlin. During his school days he would frequently visit his father’s laboratory and subsequently developed an interest in biochemistry.

In 1930, he graduated with a degree in Chemistry and Physiology from the Friedrich Wilhelm University at Berlin.

Career

After completing his graduation, he worked at the Charité Hospital in Berlin for three years. During this period, he focused on enzyme research.

With the Nazis coming into power he realized that Germany would not be safe for him as he was a Jew. On 2 April 1933, he shifted to London, England. Upon arriving in England, with the assistance of renowned scientist J.B.S. Haldane he received an opportunity to work at the University College Hospital, London.

After a few months, he was accepted as a PhD student at the Fitzwilliam House affiliated with Cambridge University. At the university, he studied phospholipids under the guidance of biochemist Frederick Gowland Hopkins.

In 1935, he began working at the Sir William Dunn School of Pathology of the Oxford University. The following year he was made demonstrator and lecturer in chemical pathology.

While pursuing his career as a lecturer, he simultaneously conducted extensive research on diverse areas that include studying the metabolism of tumours, understanding biochemistry techniques, conducting research on lysosomes and snake venom.

In 1939, he, along with Australian pathologist and pharmacologist, Howard Florey, engaged in intensive research on natural antibacterial agents generated by microorganisms.

These studies led to the revisiting the works of biologist Alexander Fleming. Alexander Fleming had explained in detail about the penicillin mold almost a decade earlier. Ernst Boris Chain along with Howard Florey worked on the chemical structure and therapeutic characteristics of Penicillin.

He developed theory on the structure of the antibiotic that was later confirmed through X-Ray Crystallography by biochemist Dorothy Hodgkin. This research earned them the Nobel Prize in 1945.

Penicillin was widely used for the treatment of the armed forces during the World War II. After the war it was made available for civilian use as well.

Post the World War II, he shifted to Rome and joined the Istituto Superiore di Sanità as the Scientific Director of the International Research Centre for Chemical Microbiology at the Institute, in 1948. He remained in the institute till 1961.

In 1961, he moved to Britain and was appointed as the Founder and Head at the Department of Biochemistry at the Imperial College in London. He remained in the college until his retirement in 1973. Post his retirement, he continued to deliver lectures.

His research work during the later years of his career included studies on fermentation technology, production of lysergic acid in a submerged culture, segregation of new fungal metabolites and the carbohydrate-amino acid relationship in nervous tissue.

Major Works

Ernst Boris Chain was a renowned biochemist who was instrumental in refining penicillin and developing the primary antibiotic drug.

Awards & Achievements:

He along with Alexander Fleming and Howard Florey received the Nobel Prize for Physiology or Medicine in 1945.

In 1946 he received the Silver Berzelius Medal of the Swedish Medical Society. The following year he was made a commander of the Legion d'Honneur.

In 1954, he received the Paul Ehrlich Centenary Prize.

In 1957, he was gifted with the Gold Medal for Therapeutics of the Worshipful Society of Apothecaries of London.

In 1969, he was knighted by Queen Elizabeth II.

He was bestowed honorary degrees from the universities of Bordeaux, Paris, La Plata, Cordoba, Montevideo, Turin and Brazil.

He was also a member of numerous learned societies across several countries like the New York Academy of Medicine, Académie des Sciences in Paris, the Weizmann Institute of Science in Israel, National Institute of Sciences in India and the Finnish Biochemical Society, to name a few.

Personal Life & Legacy

Ernst Boris Chain married biochemist Annie Chain Beoff-Chain in 1948. The couple had three children; two sons Benjamin and Daniel, and a daughter named Judith.

He died of heart failure on 12 August 1979, at Mayo General Hospital, in Castlebar, Ireland.

Trivia

The biochemistry building of the Imperial College in London is named after Ernst Boris Chain.

A road in the county town of Castlebar in Ireland is also named after him.

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Ernst Boris Chain's awards

YearNameAward

Other

01945 - Nobel Prize in Physiology or Medicine
0 1954 - Paul Ehrlich and Ludwig Darmstaedter Prize

Ernst Boris Chain biography timelines

  • // 19th Jun 1906
    Ernst Boris Chain was born on 19 June 1906, at Berlin, to chemist and industrialist, Dr. Michael Chain, and his wife, Margarete Eisner.
  • // 1930
    In 1930, he graduated with a degree in Chemistry and Physiology from the Friedrich Wilhelm University at Berlin.
  • // 2nd Apr 1933
    With the Nazis coming into power he realized that Germany would not be safe for him as he was a Jew. On 2 April 1933, he shifted to London, England. Upon arriving in England, with the assistance of renowned scientist J.B.S. Haldane he received an opportunity to work at the University College Hospital, London.
  • // 1935
    In 1935, he began working at the Sir William Dunn School of Pathology of the Oxford University. The following year he was made demonstrator and lecturer in chemical pathology.
  • // 1939
    In 1939, he, along with Australian pathologist and pharmacologist, Howard Florey, engaged in intensive research on natural antibacterial agents generated by microorganisms.
  • // 1945
    He developed theory on the structure of the antibiotic that was later confirmed through X-Ray Crystallography by biochemist Dorothy Hodgkin. This research earned them the Nobel Prize in 1945.
  • // 1945
    He along with Alexander Fleming and Howard Florey received the Nobel Prize for Physiology or Medicine in 1945.
  • // 1946
    In 1946 he received the Silver Berzelius Medal of the Swedish Medical Society. The following year he was made a commander of the Legion d'Honneur.
  • // 1948 To 1961
    Post the World War II, he shifted to Rome and joined the Istituto Superiore di Sanità as the Scientific Director of the International Research Centre for Chemical Microbiology at the Institute, in 1948. He remained in the institute till 1961.
  • // 1948
    Ernst Boris Chain married biochemist Annie Chain Beoff-Chain in 1948. The couple had three children; two sons Benjamin and Daniel, and a daughter named Judith.
  • // 1954
    In 1954, he received the Paul Ehrlich Centenary Prize.
  • // 1957
    In 1957, he was gifted with the Gold Medal for Therapeutics of the Worshipful Society of Apothecaries of London.
  • // 1961 To 1973
    In 1961, he moved to Britain and was appointed as the Founder and Head at the Department of Biochemistry at the Imperial College in London. He remained in the college until his retirement in 1973. Post his retirement, he continued to deliver lectures.
  • // 1969
    In 1969, he was knighted by Queen Elizabeth II.
  • // 12th Aug 1979
    He died of heart failure on 12 August 1979, at Mayo General Hospital, in Castlebar, Ireland.

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Ernst Boris Chain's FAQ

  • What is Ernst Boris Chain birthday?

    Ernst Boris Chain was born at 1906-06-19

  • When was Ernst Boris Chain died?

    Ernst Boris Chain was died at 1979-08-12

  • Where was Ernst Boris Chain died?

    Ernst Boris Chain was died in Castlebar, Republic of Ireland

  • Which age was Ernst Boris Chain died?

    Ernst Boris Chain was died at age 73

  • Where is Ernst Boris Chain's birth place?

    Ernst Boris Chain was born in Berlin, Germany

  • What is Ernst Boris Chain nationalities?

    Ernst Boris Chain's nationalities is German

  • Who is Ernst Boris Chain spouses?

    Ernst Boris Chain's spouses is Anne Chain (m. 1948–1979), his death)

  • What is Ernst Boris Chain's sun sign?

    Ernst Boris Chain is Gemini

  • How famous is Ernst Boris Chain?

    Ernst Boris Chain is famouse as Biochemist