Richard J. Roberts

Roberts married Jean and has four children, namely Alison, Andrew, Christopher and Amanda.

In 2005, the chemistry department at his alma mater, University of Sheffield, was later named after him.

Richard John Roberts was born on September 6, 1943 in Derby, England, to Edna Allsop and John Roberts. His father was an auto mechanic by profession while his mother was a homemaker.

When young Robert was just four, the family shifted to Bath. There, he attended the Christ Church infant school and later St Stephen’s Boys’ School. It was at Stephen’s that Roberts developed a passion for logic and mathematics. He was encouraged by his headmaster, Mr Broakes who would spend hours producing problems and later helping Roberts solve them.

Completing his elementary studies, he attended City of Bath Boys’ School. Early on, Robert aimed at becoming a detective but when he was handed a chemistry play set, he changed his mind. His chemistry play set was transformed into a large in-house chemistry laboratory that comprised of real apparatus and chemicals. He soon found his real calling in chemistry.

Following his preliminary education, he enrolled at the University of Sheffield. He graduated from the same with a Bachelor of Science degree in Chemistry in 1965. Four years later, he attained his PhD in the subject, his thesis being in phytochemical studies of neoflavonoids and isoflavonoids.

While doing his Ph.D, Richard J. Roberts came across a book by John Kendrew that turned his focus to molecular biology. The book detailed the early history of crystallography and molecular biology focussing on MRC Laboratory in Cambridge.

For postdoctoral studies, Roberts looked for a laboratory that would provide him the pathway into molecular biology. At Harvard, Jack Strominger offered him an opportunity. He engaged himself in the research work from 1969 to 1972.

In September 1972, he moved to Cold Spring Harbor Laboratory where he worked under James Dewey Watson, co-discoverer of the structure of DNA. Same year, he attended a seminar by Dan Nathans who described an enzyme Endonuclease R that could cleave DNA into specific pieces. Roberts realized that Nathans' restriction enzyme gave an immediate way to isolate small DNA molecules.

At Cold Harbor Laboratory, he made preparations of Endonuclease R and the few other restriction enzymes known then. By 1973, he had found superlative success in restriction enzyme. Almost three quarter of the world’s first restriction enzymes were discovered or characterized under his guidance. He had complied an enzyme collection that proved to be a valuable resource for scientists around the world.

In 1974, Roberts was joined by Richard Gelinas to characterize the initiation and termination signals for an Adenovirus-2mRNA. The main purpose was to sequence the 5'-end of an mRNA, map its location on a restriction fragment, and then sequence the upstream region. Just before beginning the project, mRNA caps were discovered. The duo developed an assessment of the capped oligonucleotides.

Richard J. Roberts’ most distinguished work came in 1970s when he successfully discovered split genes. The discovery was crucial and important in the scientific world as until then, scientists believed that the genes consisted of unbroken stretches of DNA, of which encoded protein structure. It was Roberts who established the discontinuous gene structure. Through his experiments, he proved that the segments of DNA that code for proteins are interrupted by lengthy stretches of DNA that do not contain genetic information. He demonstrated how RNA can be divided up into introns and exons, after which the exons can be joined together. This can occur in different ways, giving a gene the potential to form a number of different proteins.