François Jacob

He married pianist Lise Bloch in 1947. They were blessed with three sons and one daughter. Their four children were Pierre (born in 1949); Odile and Laurent (born in 1952) and Henri (born in 1954). His wife Lise died in 1983.

In 1999 Jacob married for the second time to Geneviève Barrier.

On April 19, 2013, he died in Paris, France, at the age of 92 survived by his second wife Geneviève and four children from his first marriage.

He was born on June 17, 1920, Nancy, France, to Thérèse (Franck) Jacob and his wife Simon as their only child. His father was a "conformist in religion", while his mother and other close family members were secular Jews.

When he was seven-year-old he joined the public secondary and higher education school ‘Lycée Carnot’ in Paris and studied there for ten years.

As a child he looked up to his maternal grandfather Albert Franck, a four-star general. Jacob became an atheist some time after his bar mitzvah.

After completing school education he enrolled at the Faculty of Paris with the objective of becoming a surgeon and studied medicine. However his studies were interrupted during the ‘Second World War’ in 1940 when the German Army invaded France.

While in his second year of studies he fled to England in a boat in June 1940 and joined the ‘Free French Forces’ in London. Jacob was relocated to Africa where he served as a medical officer and witnessed several actions in Libya, Tunisia, Tripolitania and Fezzan.

He joined the renowned ‘Pasteur Institute’ of France in 1950 as a research assistant and began working under French microbiologist Dr. André Lwoff. The following year he received his science degree.

His work centred on the genetic mechanisms present in bacteriophages and bacteria as also with regard to the biochemical effects of mutations. He examined properties of lysogenic bacteria and showed their immunity.

In 1954 he earned his PhD. in science from the ‘University of Paris’ (Sorbonne) submitting his thesis on ‘Lysogenic bacteria and the provirus concept’. The same year he started collaborating with French microbial geneticist, Elie Wollman and examined the relation between the genetic substance of bacteria and prophage. The investigation resulted in defining the mechanics of unification of bacteria as also facilitated a research of the genetic device of the bacterial cell. The work led to a number of new concepts like the procedure of genetic transfer from male to female and the episome concept. A summary of this work was given by him in the book ‘Sexuality and the Genetics of Bacteria’, which was published in 1961.

In 1956 he was made the Laboratory Director at the ‘Pasteur Institute’ and after a few years in 1960 he became the Head of the Department of Cell Genetics, a position which was created sometime recently.

In 1961 Jacob along with Jacques Monod investigated on the mechanics that are responsible for genetic data transfer and the controlling pathways present in bacterial cell that regulate the activities and synthesis of macromolecules. The duo suggested a number of new concepts like those of allosteric proteins, regulator genes and messenger RNA.

In 1965 he received the ‘Nobel Prize in Physiology or Medicine’ together with Jacques Monod and Andre Lwoff.