Thomas Robert Cech is an American chemist who was jointly awarded the ‘Nobel Prize in Chemistry’ in 1989
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Thomas Robert Cech is an American chemist who was jointly awarded the ‘Nobel Prize in Chemistry’ in 1989
Thomas Cech born at
He married Carol Lynn Martinson, his lab partner of organic chemistry from his graduating years, in 1970. Thereafter they both joined the ‘University of California’ to pursue their PhD and obtained it in 1975.
The couple is blessed with two daughters Allison, born in 1982 and Jennifer born in 1986.
He was born on December 8, 1947, in Chicago to a physician father and a homemaker mother, both of whom were of Czech origin. He was brought up in Iowa City, Iowa, along with his two siblings, Richard and Barbara.
Although a physician, his father’s love for physics besides medicine introduced a scientific viewpoint invariably in most of their conversations that probably infused an interest on science in Cech from an early age. By the time he was in fourth grade, he started collecting minerals and rocks that made him curious about the way these were formed.
His curiosity increased with time and by the time he started studying in junior high school, he would knock the doors of Geology professors at the ‘University of Iowa’ and request them to show models of crystal structures and discuss about fossils, meteorites and crystal structures.
He joined a private liberal arts college, the ‘Grinnell College’ in Grinnell, Iowa in 1966. There he studied ‘Odyssey, one of two main ancient Greek epic poems by Homer; ‘Inferno’, the first part of the 14th-century epic poem ‘Divine Comedy’ by Dante Alighieri; Chemistry and Constitutional History.
In 1970 he completed his graduation with a B.A.
He joined the ‘University of Colorado Boulder’ (also referred as ‘UCB’, ‘CU, Boulder’ and ‘CU-Boulder’) in 1978 in a faculty position and taught chemistry and biochemistry to undergraduate students. Since 1990 till present he serves the university as Distinguished Professor in the Department of Chemistry and Biochemistry.
The primary research area of Cech has been the method of transcription, the very first step of gene expression, in nucleus of cells, where the enzyme RNA polymerase copies a specific segment of DNA, a molecule that carries much of the genetic instructions, into the RNA (mRNA).
During the 1970s he was examining RNA splicing of Tetrahymena thermophila, a unicellular pond organism, and found that an RNA molecule which is unprocessed can splice itself.
In 1982 he and his research team were the first to declare that in absence of proteins an RNA molecule of Tetrahymena thermophila can cut and rejoin chemical bonds. Thus they became the first to show that RNA is not only a passive carrier of genetic data but they can have catalytic functions and can take part in reactions of cells.
This finding of self-splicing RNA by Cech changed the earlier perception that proteins only function as catalysts in biological reactions.
His pioneering discovery of catalytic RNA changed the earlier tenets of biosciences and researchers who perceived RNA of living cells to be passive became aware that RNA can behave as an enzyme and work as a catalyst. These findings have provided a new device in the technology of genes and also led to the revision of chemistry and biology textbooks. The RNA enzymes also have the ability to provide new therapeutic agents.
The discovery of telomerase reverse transcriptase (TERT) is aiding scientists in comprehending the behaviour of HIV in a better way.