Philip Showalter Hench

In 1927, Philip S. Hench married Mary Genevieve Kahler. The couple was blessed with four children, two sons and two daughters.

Apart from science, Hench was interested in music, photography and tennis.

He died of pneumonia on March 30, 1965, while on a vacation in Ocho Rios, Jamaica.

Philip Showalter Hench was born to Jacob Bixler Hench and Clara Showalter on February 28, 1896, in Pittsburgh, Pennsylvania.

He completed his formal education from local schools. He then enrolled at Lafayette College, Easton graduating from the same with a Bachelor degree in Arts in 1916.

In 1917, Hench enlisted himself at the medical corps of the United States Army but was transferred to the reserve corps to finish his medical training.

In 1920, Hench gained doctorate degree in medicine from the University of Pittsburgh. Following his doctorate degree, he interned at the Saint Francis Hospital, Pittsburgh for a year before becoming a Fellow of the Mayo Foundation, the graduate school of the University of Minnesota's Department of Medicine.

In 1923, Hench took up the post of an assistant at the Mayo Clinic. Within three years, he was promoted as the Head of the Department of the Rheumatic Diseases.

From 1928 to 1929, he studied at Freiburg University and at the von Müller Clinic, Munich. In 1928, he was appointed an instructor in the Mayo Foundation. In 1932, he became Assistant Professor, in 1935, Associate Professor and in 1947, Professor of Medicine.

At Mayo Clinic, Hench specialized in arthritis. He made detailed observations which led him to hypothesize that steroids had a curative effect on arthritis. They helped in alleviating pain that the disease caused.

In the period between 1930 and 1938, he befriended Edward Calvin Kendall, who had isolated several steroids from the adrenal gland cortex. Together, the two decided to try the effect of Compound E, one of the substances, on rheumatoid arthritis patients. However, they weren’t able to conduct the test successfully until 1948, as Compound E was both costly and its isolation a complicated and time-consuming process.

After his service in the military during World War II, Hench continued his scientific career. In 1948 and 1949, Hench together with Kendall and Swiss chemist Tadeus Reichstein successfully conducted experiments which helped them make discoveries relating to hormones of the adrenal cortex, their structure and biological effects. Their work won them a Nobel Prize in Physiology or Medicine in 1950.

Hench’s most significant work came in 1948 and 1949. He, together with Kendall and Reichstein, discovered the hormone cortisone and its application for the treatment of rheumatoid arthritis. This discovery of the hormones of the adrenal cortex, their structure and biological effects were instrumental in finding the cure to rheumatoid arthritis.