Heinrich Otto Wieland

In 1908, Wieland married Josephine Bartmann Wieland. The couple had three sons and one daughter. His eldest son, Wolfgang Wieland, was a doctor of pharmaceutical chemistry, his second son Theodor Wieland was a professor of chemistry; his third son Otto Wieland was a professor of medicine. His daughter, Eva Wieland Lynen, was married to Nobel Prize winning German biochemist Feodor Lynen.

Wieland died on 5 August 1957, in Starnberg from natural causes. He was few months short of eighty at the time of his death.

In 1963, Heinrich Wieland Prize was established in his honor by Mergarine Institute in support of researches in the field of lipid. However, from 2000, Boehringer Ingelheim began to sponsor the prize and now it covers researches on a wider range of subjects.

Heinrich Otto Wieland was born on 4 June 1877, in Pforzheim, an ancient town in the federal state of Baden-Württemberg, in the southwest of Germany. At the time of his birth, the town was known for its jewelry and watch-making industry.

Heinrich’s father, Theodor Wieland, also owned a gold and silver refinery in the town. In addition, he was a pharmacist with a doctorate in chemistry. His mother’s name was Elise Blum Wieland. Nothing is known about his yearly years except that he had his schooling at Technical High School in Stuttgart.

Later he studied at the Universities of Munich, Berlin and Stuttgart. Finally he returned to Munich to work for his doctoral thesis at Baeyer Laboratory under Johannes Thiele. He received the PhD degree in 1901 and completed habilitation in 1904.

In 1904, Wieland started his academic career at the Ludwig Maximilian University of Munich. In 1907, he was appointed as a consultant at Boehringer Ingelheim GmbH, a pharmaceutical company, located at Ingelheim am Rhein, but continued teaching as well as research work at the University.

In 1911, Wieland found that it was possible to detect and distinguish different forms of nitrogen in organic compounds. This discovery is considered to be one of the important milestones in the development of structural organic chemistry.

Subsequently, he started working on bile acids, produced by our lever and published his first paper on that topic in 1912. He continued on working on that topic for two more decades and the final paper was published in 1932.

In 1913, Wieland became an Associate Professor in Organic Chemistry at Technical University of Munich. Next in 1915, he became an advisor at the Boehringer Ingelheim GmbH and set up the first scientific department of the company.

Also in 1915, he was able to synthesize an organic compound called arsenical diphenylaminechlorarsine, to be used as riot control agent. Unfortunately, his discovery did not get much notice. It was later named Adamsite after Roger Adam, who developed it independently in 1918 at the University of Illinois, USA.

Heinrich von Wieland is best known for his work on the molecular structure of bile acid. Early in 1911, he isolated three acids; namely the cholic acid, deoxycholic acid, and lithocholic acid. Later he showed that they were steroids of similar structure and were related to cholesterol.

Oxidation processes in living cells also interested him a great deal. After extensive research he found that the process involves dehydrogenation, removing hydrogen atoms from the cell, rather than adding oxygen.

His work on organic nitrogen compounds such as nitrogen oxides also merits especial mention. He was first to produce stable organic nitrogen radicals like diphenyl nitrogen and its N-oxide. His work in this respect contributed significantly in the development of organic radical chemistry.

His works also helped to clarify the structure of morphine and strychnine. He also contributed to the constitution and synthesis of the lobelia alkaloid and the research into the curare alkaloid.