Eric F. Wieschaus

While Wieschaus was a postdoctoral fellow at Zurich he met his future wife, Gertrud Schüpbach; (published name Trudi Schüpbach), a Swiss-American molecular biologist. They got married in 1983 at Princeton. The couple has three daughters; Ingrid, Eleanor and Laura.

Trudi Schüpbach is now a Professor of Molecular Biology at Princeton University and works mainly on molecular and genetic mechanisms in Drosophila oogenesis. On occasions, she has also collaborated with her husband.

Wieschaus has always been pacifist. In his years at the University of Notre Dame, he actively agitated against the war in Vietnam. He not only collected petitions, but also joined in protest demonstrations. He even applied for conscientious objector status to avoid going to Vietnam

Erik Francis Wieschaus was born on June 8, 1947, in South Bend, Indiana. When he was six years old, his family moved to Birmingham, Alabama, which still retained its small town characteristics. Here, he spent a lot of time exploring the woods near his home with his siblings, collecting frogs, crayfish and turtles.

At the age of fourteen, Erik was admitted to John Carroll Catholic High School. Although he was good in science subjects, becoming a scientist was never his goal. Instead he wanted to become an artist and spent a lot of time painting. He was also fond of reading books and playing the piano.

His interest in science began to develop when he attended a program funded by the National Science Foundation at Lawrence, Kansas. It was meant to encourage high school kids to become scientists. Here he dissected different kinds of animals, starting from fish to fetal pigs.

In the following summer, he had the good fortune of attending the neurobiology laboratory of Nancy and Dennis Dahl. This time he got the opportunity to experiment with a large tortoise, stripping of its outer sheathe, removing its vagus nerve and recording the electrical depolarization when they were stimulated.

In 1965, Erik graduated from school and entered University of Notre Dame, near South Bend. By this time he had decided to major in biology. As he needed money, he found a job in the Drosophila laboratory of Professor Harvey Bender, where his task was to prepare fly food.

In 1975, Eric Francis Wieschaus joined Zoologisches Institut der Universität Zürich, Switzerland as a postdoctoral Fellow under Dr Rolf Nöthiger. Here he remained till 1978 and focused mainly on the development of sexually dimorphic structures.

Meanwhile in 1976, he also worked in the laboratory of Mme Gans at Laboratoire de Genetique Moleculaire at Gif-sur-Yvette, France, on a short-term fellowship. The following year, for a brief period, he was also a visiting researcher at Laboratory of Peter Bryant, Center of Pathobiology at the University of California.

In 1978, Wieschaus was appointed a Group Leader at European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. It was his first independent job. Moreover, it gave him the opportunity to pursue his work on embryology freely. There was no teaching obligation and grants were easy to get.

Here he shared the laboratory with Christiane (Janni) Nüsslein-Volhard, whom he had met while working at Basel and with whom he had developed a close friendship. Although both were Group Leaders and had their individual projects they spent a lot of time together, working on the joint mutagenesis experiment.

In 1980, working with around 40000 families of Drosophila, they succeeded in identifying 139 genes that were essential for transforming a Drosophila egg into an embryo. Moreover, they also classified these genes. Almost fifteen years later, they received the Nobel Prize for this work.

Eric Francis Wieschaus is best remembered for his work on identification of 139 genes essential for transforming a newly fertilized Drosophila egg into an embryo. It was a huge task and no other researchers had tried to do that before.

In 1978, he and Christiane Nüsslein-Volhard set upon a trial and error method, with the aim of identifying which of Drosophila’s 20,000 genes were absolutely essential for its early development. First they randomly created mutations in the Drosophilae that ‘knocked out’ the function of individual genes.

Subsequently they bred 40,000 drosophila families that have defective genes. On examining them they finally found 5000 genes that were important for the embryonic developments, among which 139 genes proved to be essential. Drosophilae born without these 139 genes lacked in vital body parts like muscles, eyes, heads etc. In 1980, they published the result in the scientific journal ‘Nature’.