Scientists and medical experts have discovered the reason why CAR-T immunotherapy has a weaker effect on solid cancers than blood diseases. The tonic signal generated by CAR exhausts the energy and patience of T cells, whose anti-cancer function fails. Experts have developed two solutions to reduce the tonic signal during CAR-T therapy development targeting neck tumors, which can significantly reduce CAR-T cell exhaustion and improve anti-cancer effects. This breakthrough discovery has been published in Cell Research, a world-leading journal in the scientific and medical field, and is considered one of the top articles in the past three years. The research is a hot topic globally and will pave the way for more effective treatment for solid cancers in the future. CAR-T immunotherapy is a significant breakthrough in cancer treatment, and this discovery will help improve the precision and effectiveness of cancer treatment.
Breakthrough in Cancer Treatment Uncovered by Local Experts
Scientists and medical experts from ShanghaiTech University, Chinese Academy of Sciences, Eye, Ear, Nose and Throat Hospital of Fudan University, and Shanghai General Hospital have made a significant discovery related to CAR-T immunotherapy. CAR-T, or Chimeric Antigen Receptor T-Cell Immunotherapy, is a biological immunotherapy process that involves taking T cells, a type of immune cells, from the patient and adding a chimeric antibody through genetic engineering. The antibody acts as a navigator to help T cells recognize cancer cells and activate T cells’ ability to destroy cancer cells. These CAR-T cells are then transported back into the patient’s body after being amplified in vitro. Compared to other biological immunotherapy, CAR-T treatment is more precise and targeted to cancer.
However, CAR-T treatment has a weaker effect on solid cancers than blood diseases. The reason behind this is that CAR-T cells can become weak and exhausted as CAR generates a type of tonic signal while working on a solid cancer. The tonic signal works like an order to ask a person to repeat the same task, which exhausts his or her energy and patience. The repeated signals from CAR also cause the fatigue of T cells, whose anti-cancer function fails.
Experts discovered that electrostatic interaction caused by positively charged plaque on the surface of CAR-T cells is the reason for the tonic signal. Dr. Wu Haitao from EENT Hospital and other experts developed two solutions to reduce the tonic signal during CAR-T therapy development targeting neck tumors. Animal experiments confirmed that these methods can significantly reduce CAR-T cell exhaustion and improve anti-cancer effects.
The discovery was published in Cell Research, one of the world’s leading journals in the scientific and medical field. This research is a hot topic globally and is considered one of the journal’s top articles in the past three years. CAR-T immunotherapy is a significant breakthrough in cancer treatment, and this discovery will pave the way for more effective treatment for solid cancers in the future.
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